For the treatment and prevention of flea (Ctenocephalides felis) infestations in dogs where one or more of the following indications are required concurrently: prevention of heartworm disease (L3, L4 Dirofilaria immitis); prevention of angiostrongylosis by reducing the level of infection with immature adult (L5) Angiostrongylus vasorum; treatment of gastrointestinal nematode infections caused by hookworm (L4, immature adult, L5) and adult Ancylostoma caninum), roundworms (immature adult L5, and adult Toxocara canis and adult Toxascaris leonina) and whipworm (adult Trichuris vulpis).