linaclotide

INN (International Nonproprietary Name)

🇺🇸 Also approved in the US (FDA)

LINZESS — ABBVIE, approved 2026-05-21 (NDA202811).

Most reported adverse events (US / FAERS)

24,725 reports across the top reactions. These are spontaneously reported events from the FDA Adverse Event Reporting System — they reflect reporting volume, not incidence or frequency, and a report does not mean the drug caused the event.

diarrhoea

4,580

drug ineffective

4,430

off label use

3,279

constipation

1,937

Medicines containing this active substance

1 medicines

Constella

Authorised

🇺🇸 Also approved in the US (FDA)

LINZESS — ABBVIE, approved 2026-05-21 (NDA202811).

Most reported adverse events (US / FAERS)

24,725 reports across the top reactions. These are spontaneously reported events from the FDA Adverse Event Reporting System — they reflect reporting volume, not incidence or frequency, and a report does not mean the drug caused the event.

diarrhoea

4,580

drug ineffective

4,430

off label use

3,279

constipation

1,937

nausea

1,414

fatigue

1,143

abdominal distension

1,134

abdominal pain

1,041

headache

1,007

pain

928

abdominal pain upper

908

dizziness

818

inappropriate schedule of product administration

739

flatulence

688

fall

679